Meanwhile, Kyle Walker-Peters and Eric Dier are also being assessed for selection after returning to training from hamstring and hip issues respectively.
However, Giovani Lo Celso has been ruled out with a hip injury until next month.
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The Real Betis loanee was being eased into the team with three substitute appearances after a busy summer at the Copa America.
But the 23-year-old suffered a setback while on international duty with Argentina.
Tottenham boss Mauricio Pochettino said: “Always it’s a sad situation, very disappointed.
“For Giovani, the first months here was to adapt to a new club and new football. Everything he was doing in a very good way. We are all so disappointed because now we need to wait for him.
“In the same way we need to be positive, it’s not another way to take it, but we need to be positive and try to provide him with good quality training and recovery.
“In the moment that he’s ready, to be strong and start to help the team again.
“Nothing that I can tell you will change his reality. We’re all disappointed, first the Argentine national team are very sad. We’re all really sad. We cannot change the situation.
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“That is why it is so important for us, we need to try to anticipate the things, the right judgement.
“The decisions are so important to have a good relationship with all the national teams.
“It’s not to blame someone. In the end the most difficult part is for the player. That is why our responsibility is always to try to anticipate the problems.”
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Given the significance of the fixture at any stage of the season, both Unai Emery and Mauricio Pochettino will be well aware a second successive defeat already at this stage of the season could be fatal.
While neither side can lay claim to having serious title ambitions, neither will want the chasm between the Reds and reigning champions Manchester City to widen any further.
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The Gunners only have one fit left-back – Sead Kolasinac – following the departure of Nacho Monreal to Real Sociedad yesterday.
Monreal had started all three of the Gunners’ opening Premier League fixtures, with Kolasinac being eased back into action after he was the victim of an attempted carjacking.
Emery is quite literally spoilt for choice in attack, but his tactical tinkering did not come off at Anfield.
The Spaniard dropped Alexandre Lacazette to the bench on Merseyside, but Nicolas Pepe and Dani Ceballos looked shaky under the intense pressing of Jurgen Klopp’s team.
Pepe and Ceballos should both still keep their places however, with Emery likely to try and attack a nervy Spurs side.
Pochettino has a selection headache ahead of Sunday’s north London derby with Tottenham missing FOUR players for the match.
Defenders Kyle Walker-Peters and Juan Foyth have both been confirmed to miss the Emirates Stadium clash, meaning Serge Aurier could play competitive club football for the first time since February.
Record signing Tanguy Ndombele is also out of the clash, meaning Pochettino is light at the back.
This issue could be solved if Eric Dier is passed fit for Sunday’s match, as he can provide cover in defence. The England international is currently being assessed due to a hip problem and is considered a doubt, as is Dele Alli.
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But Spurs boss Mauricio Pochettino is willing to be patient with the Argentina midfielder’s fitness.
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He said: “I think Lo Celso is a situation that is not going to be easy.
“He was in extended holidays after the Copa America, he didn’t have a proper pre-season and didn’t train too much.
“Then signed for us after a week without training. He’s training well but is still so far away from what we expect from him. We need to give him time.
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“He was involved [against Man City] and will maybe have the possibility to help the team in some points, but we won’t expect too much from him.
“We need to not put the responsibility on him, only to improve and adapt himself with us and see. It’s a natural process to learn and improve.
“In the moment he will be fit and deserves to play then sure he will have the chance like other players.”
Saturday is GameDay on talkSPORT and talkSPORT 2 as we become your go to destination for all the Premier League action. We’ll bring you LIVE commentary of Premier League games across all three time slots on Saturday – 12.30pm, 3pm and 5.30pm – including Liverpool vs Arsenal this weekend.
West Ham ace Declan Rice is relishing facing Tottenham this season and is particularly looking forward to playing against Tanguy Ndombele.
Ndombele joined Spurs from Lyon in a £55million transfer earlier in the summer and has impressed fans with his pre-season displays.
“I’m really looking forward to playing against Ndombele,” Rice told talkSPORT. “I watched him in the Champions League last season and he looked like a top, top player.
“The French boys here were raving about him, saying what a good player he was, so I’m looking forward to playing against Spurs and looking forward to playing against him.”
The 20-year-old, though, couldn’t resist reminding everyone that West Ham were the only side to win at the new White Hart Lane last season, but he did back the Hammers’ rivals to fight Liverpool and Man City at the top of the Premier League.
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“Everything they’re doing now and the player’s they’ve got, they’ve definitely got the squad now to be challenging up there for titles, and I wouldn’t put it past them.”
Although impressed by the business of Tottenham, as well as Arsenal, Rice is still backing West Ham to have a strong campaign as a result of their transfer business, which included the signing of Albian Ajeti on deadline day.
“We’ve really strengthened the squad as well,” the England international continued. “We’ve brought in some great players and have spent a lot of money and I think we’re one to look for this season, for sure.”
Saturday is GameDay on talkSPORT and talkSPORT 2 as we become your go-to destination for all the Premier League action. We’ll bring you three LIVE Premier League commentaries across all time slots on Saturday – 12.30pm, 3pm and 5.30pm – delivering award-winning coverage to more GameDay listeners than ever.
This week could see Spurs conclude deals for Fulham flyer Ryan Sessegnon, with a deal worth around £25m being mooted.
The Telegraph believe the move could go through as the Cottagers left-sided ace only has one year left on his current contract, while they are also interested in signing Josh Onomah and Georges-Kevin Nkoudou from Spurs.
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And, to increase their summer haul to five, they could also add Argentine superstar Giovani Lo Celso from Real Betis.
The Spanish side have just signed Nabil Fekir, who missed out on a move to Liverpool last summer, and many consider him to be the replacement for Lo Celso.
It was believed they would have to spend £60m to snag the midfielder but now Betis have signed Fekir for just £22m they could now slash their asking price to around £45m, according to The Sun.
But how will Tottenham look if they sign Sessegnon and Lo Celso?
talkSPORT.com have taken a look – and we’ve also taken into account Christian Eriksen and Toby Alderweireld staying with the club, as is currently being reported.
Should Spurs land the duo, it’s easy to see where Sessegnon would slot in at left-back but Lo Celso, along with Ndombele, could fit into a number of different roles.
Lo Celso, more often than not occupied the right side of central midfield for Betis, and could combine well with Christian Eriksen across in attacking areas to the right.
Having a left-footer in Lo Celso and a right-footer in Eriksen in a similar area of the pitch would give them the option to be versatile in attack, either going down the wing or cutting inside with combination passing.
Ndombele is likely to play on the left of the central three, with Dele Alli just wider ahead of him, attempting to win the ball and drive forward with it before handing it off to teammates.
A formation used more often than a 433 by Pochettino, this was once his go-to.
The fabled ‘DESK’ front four of Dele, Eriksen, Son, and Kane didn’t get too many outings last season due to injuries and while it’s effective it can look a little lopsided at times with that combination of players.
Bringing in Lo Celso on the right, in place of Alli, and pushing Son to the left is one way to balance the frontline.
It would see Winks and Ndombele control the midfield in deeper positions allowing Sessegnon and Aurier to drive forward offering width on the flanks and the attacking trio move into narrower positions
Pochettino had a real predilection for this formation last season with Son and Lucas Moura the men who often partnered Kane up top.
The midfield four kept opposition players on their toes and stifled teams like Chelsea who operated through a playmaking no.6.
It didn’t always work though, so the addition of Ndombele an Lo Celso, players who can progress the ball better, will give the Argentine another reason to have another crack of the whip.
It does, though, leave no room for a player like Alli, unless he is considered as a possible forward to partner Kane, with the freedom to drop deeper or wide to overload the opposition.
Spurs have a wealth of talent at centre-back, especially if Alderweireld stays.
Adding Davinson Sanchez to the backline will give Sessesgnon and Aurier more freedom for marauding runs down the flank.
Ndombele’s defensive ability, coupled with his fine passing, should allow him to operate as a no.6, ensuring Eriksen and Lo Celso can play as no.8s behind Kane and Son.
Pochettino could also drop Son and bring in Alli if he wishes to have more bodies in midfield.
The 22-year-old Frenchman penned a six-year deal and became Spurs’ second signing, following the £10m arrival of winger Jack Clarke, who was immediately loaned back to Leeds for the upcoming season.
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However, Ndombele could very well have ended up elsewhere as he was reportedly still undecided about whether he wanted to sign for Spurs when he arrived in London with his representatives, according to L’Equipe.
But with United stuttering and trying to fend off both Juventus and Real Madrid’s advances for Pogba, Spurs closed the deal.
Ndombele, 22, will bolster Spurs’ options in the middle of the park for next season.
talkSPORT.com looks at four possible midfield systems Mauricio Pochettino could play with their latest signing.
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Option 1: With Eriksen
If the 2019/20 season was to start tomorrow, this is the likely line-up for Tottenham.
Christian Eriksen, Dele Alli, Heung-min Son and Harry Winks all started the Champions League final defeat to Liverpool and now Ndombele is on board he would probably slot in a more defensive role, which is where he played at Lyon, alongside Winks.
Alli, who did not enjoy a particularly good 2018/19 campaign would have to step aside in this system.
Option 3: With Dier
But let’s not forget Spurs also have Eric Dier available, too.
It’s likely Spurs would still play a 4-2-3-1 formation with Dier and Ndombele in the defensive slots.
Dier did not start the Champions League final which suggests he’s falling slightly out of favour so will have to fight for his place in the first team especially after the Ndombele signing.
Option 4: The future?
But the signing of 22-year-old Ndombele could give Spurs supporters a peak into how their future side will look and perhaps this could mark a midfield partnership with Winks, 23.
Alli, also 23, would then play in the more advanced role especially if Eriksen leaves and this could then accommodate Lucas Moura, who was in brilliant form last season and Son either side of striker Harry Kane.
Tottenham have announced the signing of midfielder Tanguy Ndombele from Lyon for a club record £55m fee.
The 22-year-old France midfielder has penned a six-year deal and becomes Spurs’ second signing of the day following the £10m arrival of winger Jack Clarke, who was immediately loaned back to Leeds for the upcoming season.